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Position Statement: Cervical Cancer Screening


The National Association of Nurse Practitioners in Women’s Health (NPWH) supports a concerted effort to continue to improve cervical cancer screening rates and timely, appropriate follow-up and treatment when screening results are abnormal. The goal is to reduce cervical cancer incidence, morbidity, and mortality. NPWH supports ongoing research to ensure that screening guidelines are based on the best evidence available. Furthermore, NPWH supports policies at the local, state, and federal levels that ensure access to cervical cancer screening services and follow-up as needed.


At one time, cervical cancer was one of the most common causes of cancer death for women in the United States. However, over a period of four decades, widespread implementation of cervical cancer screening led to a significant decrease in mortality from cervical cancer. In 1975, the cervical cancer mortality rate was 14.8 deaths per 100,000 women, as compared with 2.3 deaths per 100,000 women in 2014.1

It is well established that high-risk types of the human papillomavirus (HPV) are the causative agents in more than 90% of cervical cancers.2,3 HPV infection, whether caused by a high-risk or a low-risk type, is usually transient, resolving on its own within 24-36 months in most women (>90%).4,5 It is persistent infection with high-risk HPV types that can lead to development of precancerous lesions/cervical intraepithelial neoplasia (CIN). Although precancerous lesions, especially those less than CIN grade 3 (CIN3), may regress spontaneously, they may also progress to invasive cervical cancer. Progression of a CIN3 lesion to cervical cancer typically takes more than 10 years.3 The relatively long time period from persistent HPV infection to the development of cervical cancer provides an opportunity to screen for both the presence of high-risk HPV and precancerous lesions.2,4,5

This understanding of the natural history of HPV infection and cervical cancer has been a driving force in the ongoing development of technological advances and evolving guidelines for cervical cancer screening and follow-up for abnormal screening results. Yet, even with this progress, the American Cancer Society estimates that 13,240 new cases of invasive cervical cancer will be diagnosed in the United States in 2018 and that 4,170 deaths from cervical cancer will occur.6 Most of these cases of cervical cancer will develop in women who have not been adequately screened.2 Furthermore, the burden of cervical cancer incidence and mortality now falls disproportionately on certain vulnerable populations because of disparities in cervical cancer screening. Eliminating these disparities must be a primary goal.

Populations identified as having lower rates of cervical cancer screening than the general population include women with lower socioeconomic status, racial/ethnic minorities, women living in rural areas, women with physical and/or intellectual disabilities, lesbians, and transgender males.6-16 Multiple factors, in many cases co-existent, lead to these disparities. As a result, multifaceted approaches to increasing cervical cancer screening rates are needed.

Barriers to cervical cancer screening for these populations entail financial, logistical, linguistic, and cultural factors, as well as misperceptions or lack of knowledge about screening and cancer.7-16 In addition, individuals from some minority populations may not seek cervical cancer screening because of embarrassment or because of unpleasant encounters or discrimination previously experienced in healthcare settings.10,12,15,16 These same barriers extend beyond screening to receiving appropriate follow-up and treatment for abnormal findings.

Recent study data demonstrate some promising innovations. Women who are under-screened or unscreened because of barriers such as embarrassment, discomfort, inconvenience, or lack of access may be receptive to self-sampling for high-risk HPV.2,17-20 Availability of trained patient navigators to address individual barriers to follow-up and treatment for abnormal findings has also shown favorable results.21-24 Use of telecolposcopy has the capacity to provide critical timely follow-up for women who lack easy access to it because of their location and the cost and time for travel to a distant setting.25,26

Ongoing research is needed to better understand these barriers and to further explore effective strategies to reach women who are inadequately screened, as well as to address follow-up and treatment concerns. Nurse practitioners (NPs) providing care for women are in an ideal position to participate in this research and in the implementation of evidence-based approaches.

Recommendations regarding which test should be used for primary screening (e.g., Pap test alone, HPV test alone, co-testing), which sampling methods are optimal, and how services are best delivered will likely continue to evolve as technology advances and more data become available. What is certain is that cervical cancer screening performed on a regular basis, with access to follow-up and early treatment, reduces cervical cancer morbidity and mortality.

Cervical cancer screening guidelines by age group are listed in Box 1.27-31 Of note, these guidelines are intended for women at average risk for developing cervical cancer. Women with certain additional risk factors may require a different screening schedule than that recommended for the general population. Women at higher than average risk include those infected with HIV or who are otherwise immunocompromised, those who were exposed to diethylstilbestrol in utero, and those previously treated for CIN grade 2 or higher. Also of note, the same cervical cancer screening recommendations apply to any individual with a cervix, regardless of gender identity.32

Implications for women’s healthcare and NP practice

Identifying populations within one’s own community that are facing barriers to cervical cancer screening and follow-up is essential as a first step. Use of a variety of evidence-based strategies can reduce barriers and facilitate preventive healthcare for these populations. NPs can participate in community-based approaches to reach vulnerable populations with culturally appropriate education focused on addressing misperceptions and lack of knowledge about screening and cervical cancer.

Women who have been undergoing annual cervical cancer screening may be confused by the change in recommended screening frequency for their age group. Women who have received HPV vaccination may believe that they have ensured themselves lifelong immunity to HPV infection and that they can forgo regular cervical cancer screening. Providing women with the information they need to be empowered to attend to their own health promotion and disease prevention needs is crucial.

For women aged 65 years or older, careful review of their health histories is needed to confirm that they meet certain criteria before discontinuing cervical cancer screening. A large study showed that most cervical cancers in women aged 65 or older occurred among those who had not met criteria for stopping screening.33 NPs should not make assumptions that a woman has undergone recommended screenings prior to age 65. In 2015, the National Center for Health Statistics reported that 1 in 4 women aged 45-64 years had not been screened for cervical cancer in the preceding 3 years.34

Effective reminder and follow-up systems are crucial. NPs who provide women’s healthcare must be innovative in designing and implementing reminder systems that reach all patients and engage them to return for both routine screening and any additional follow-up needed. NPs who provide women’s healthcare are also in an opportune position to participate in surveillance to track outcomes of screening and follow-up strategies. The data obtained can drive informed decision making about what works to improve cervical cancer screening and to improve service delivery.35

Improving cervical cancer screening rates and HPV vaccination rates go hand in hand to reduce the incidence of cervical cancer. NPs must also take steps in their clinical practice to identify patients who need HPV vaccination, strongly recommend this vaccination, provide the vaccination on the same day that the need is identified, and use reminder systems to ensure patients return to the office to complete the vaccination series. Useful resources are available in Box 2.

Box 2. Useful resources

  • ASCCP Mobile Consensus Guidelines on Management of Women with Abnormal Cervical Cancer Screening Tests and Cancer Precursors Available for iPhone, iPad, Android ($9.99)
  • CDC National Breast and Cervical Cancer Early Detection Program (NBCCEDP) The program helps low-income, uninsured, and underinsured women gain access to breast and cervical cancer screening, diagnostic testing, and treatment services.
  • CDC. Increasing Population-based Breast and Cervical Cancer Screenings: An Action Guide to Facilitate Evidence-based Strategies. Atlanta, GA: CDC, U.S. Department of Health and Human Services; 2014.
  • Multidisciplinary Steering Committee of the Womenʼs Preventive Services Initiative. Recommendations for Preventive Services for Women Final Report to the U.S. DHHS, Health Resources & Services Administration. Washington, DC: ACOG; 2017.
  • NPWH Well-Woman Visit App Available for iPhone, iPad, Android (free)


NPs who provide healthcare for women aged 21 years or older should:

  • Identify those populations in the community they serve who are at risk for not receiving regular cervical cancer screening and follow-up.
  • Advocate for culturally appropriate outreach to populations in the community they serve who are at risk for not receiving regular cervical cancer screening and follow-up.
  • Create healthcare environments that are welcoming and nonjudgmental and that promote a comfortable, affirming cervical cancer screening experience.
  • Follow current cervical cancer screening guidelines.
  • Educate patients about current cervical cancer screening guidelines.
  • Utilize effective reminder and follow-up systems.
  • Establish resources for referral and treatment.
  • Confirm the status of every patient aged 65 years or older to determine whether she meets criteria to discontinue cervical cancer screening.
  • Advocate for accessible and affordable cervical cancer screening services.
  • Participate in surveillance programs to track outcomes of cervical cancer screening and follow-up strategies.
  • Recommend and provide HPV vaccination when indicated.

NPWH will provide leadership and resources to ensure that:

  • Continuing education programs are available for NPs to learn about evidence-based strategies to improve cervical cancer screening rates as well as timely follow-up and treatment.
  • NPs have resources to develop and/or implement community-based approaches to reach vulnerable populations for cervical cancer awareness, screening, and follow-up.
  • Timely updates are provided on cervical cancer screening guidelines.
  • NPs have an opportunity to participate in surveillance programs to obtain data on what works to improve cervical cancer screening rates.
  • Research moves forward in all aspects of cervical cancer prevention, screening, and treatment to improve healthcare outcomes.
  • Policies support equitable access to cervical cancer screening, appropriate follow-up, and treatment when needed.


  1. National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) Program. Cancer Stat Facts: Cervical Cancer. 2017.
  2. Kaiser Permanente Research Affiliates Evidence-based Practice Center. Evidence Synthesis Number 158. Screening For Cervical Cancer With High-Risk Human Papillomavirus Testing: A Systematic Evidence Review for the U.S. Preventive Services Task Force. Rockville, MD: Agency for Healthcare Research and Quality; September 2017. Publication No. 17-05231-EF-1.
  3. Moscicki AB, Schiffman M, Burchell A, et al. Updating the natural history of human papillomavirus and anogenital cancers. Vaccine. 2012;30(suppl 5):F24-F33.
  4. Insinga RP, Dasbach EJ, Elbasha EH, et al. Incidence and duration of cervical human papillomavirus 6, 11, 16, and 18 infections in young women: an evaluation from multiple analytic perspectives. Cancer Epidemiol Biomarkers Prev. 2007;16(4):709-715.
  5. Plummer M, Schiffman M, Castle PE, et al. A 2-year prospective study of human papillomavirus persistence among women with a cytological diagnosis of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion. J Infect Dis. 2007;195(11):1582-1589.
  6. American Cancer Society. Cancer Facts & Figures 2018.
  7. White A, Thompson TD, White MC, et al. Cancer Screening Test Use — United States, 2015. Morb Mortal Wkly Rep. 2017;66(8):201-206.
  8. Akinlotan M, Bolin JN, Helduser J, et al. Cervical cancer screening barriers and risk factor knowledge among uninsured women. J Community Health. 2017;42(4):770-778.
  9. DeSantis CE, Siegel RL, Sauer AG, et al. Cancer statistics for African Americans, 2016: progress and opportunities in reducing racial disparities. CA: Cancer J Clin. 2016;66(4):290-308.
  10. Gonazalez P, Castaneda SF, Mills PJ, et al. Determinants of breast, cervical and colorectal cancer screening adherence in Mexican-American women. J Community Health. 2012;37(2):421-433.
  11. Siegel RL, Fedewa SA, Miller KD, et al. Cancer statistics for Hispanics/Latinos 2015. CA: Cancer J Clin. 2015;65(6):457-480.
  12. Schoenberg NE, Studts CR, Hatcher-Keller J, et al. Patterns and determinants of breast and cervical cancer non-screening among Appalachian women. Women Health. 2013;53(6):552-571.
  13. Andresen EM, Peterson-Besse JJ, Krahn GL, et al. Pap, mammography, and clinical breast examination screening among women with disabilities: a systematic review. Womens Health Issues. 2013;23(4):e205-e214.
  14. Parish SL, Swaine JG, Son E, Luken K. Determinants of cervical cancer screening among women with intellectual disabilities: evidence from medical records. Public Health Rep. 2013;128(6):519-526.
  15. Tracy JK, Schluterman NH, Greenberg DR. Understanding cervical cancer screening among lesbians: a national survey. BMC Public Health. 2013;13(442):1-9.
  16. Peitzmeier SM, Khullar S, Reisner SL, Potter J. Pap test use is lower among female-to-male patients than non-transgender women. Am J Prev Med. 2014;47(6):808-812.
  17. Catarino R Jr, Vassilakos P, Stadali-Ullrich H, et al. Feasibility of at-home self-sampling for HPV testing as an appropriate screening strategy for nonparticipants in Switzerland: preliminary results of the DEPIST study. J Low Gen Tract Dis. 2015;19(1):27-34.
  18. Crosby RA, Hagensee ME, Vanderpool R, et al. Community-based screening for cervical cancer: a feasibility study of rural Appalachian women. Sex Transm Dis. 2015;42(11):607-611.
  19. Penaranda E, Molokwu J, Hernandez I, et al. Attitudes toward self-sampling for cervical cancer screening among primary care attendees living on the US-Mexico border. South Med J. 2014;107(7);426-432.
  20. Winer RL, Gonzales AA, Noonan CJ, et al. Assessing acceptability of self-sampling kits, prevalence, and risk factors for human papillomavirus infection in American Indian women. J Community Health. 2016;41(5):1049-1061.
  21. Freund KM, Battaglia TA, Calhoun E, et al. Impact of patient navigation on timely cancer care: the Patient Navigation Research Program. J Natl Cancer Inst. 2014;106(6):1-9.
  22. Luckett F, Pena N, Vitonis A, et al. Effect of patient navigator program on no-show rates at an academic referral colposcopy clinic. J Womens Health (Larchmt). 2015;24(7):608-615.
  23. Paskett ED, Dudley D, Young GS, et al. Impact of patient navigation interventions on timely diagnostic follow up for abnormal cervical cancer screening. J Womens Health (Larchmt). 2016;25(1):15-21.
  24. Simon MA, Tom LS, Nonzee NJ, et al. Evaluating a bilingual patient navigation program for uninsured women with abnormal screening tests for breast and cervical cancer: implications for future navigator research. Am J Public Health. 2015;105(5):e87-e94.
  25. Hitt WC, Low GM, Lynch CE, et al. Application of a telecolposcopy program in rural settings. Telemed J E Health. 2016;22(10):816-820.
  26. Hitt WC, Low G, Bird TM, Ott R. Telemedical cervical cancer screening to bridge Medicaid service gap for rural women. Telemed J E Health. 2013;19(5):403-408.
  27. Saslow D, Solomon D, Lawson HW, et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. J Low Genit Tract Dis. 2012;16(3):175-204.
  28. Smith RA, Andrews KS, Brooks D, et al. Cancer screening in the United States, 2017: a review of current American Cancer Society guidelines and current issues in cancer screening. CA Cancer J Clin. 2017;67(2):100-121.
  29. Committee on Practice Bulletins—Gynecology. Practice Bulletin #168: Cervical Cancer Screening and Prevention. Obstet Gynecol. 2016:128(4):e111-e130.
  30. Moyer VA; U.S. Preventive Services Task Force. Screening for cervical cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2012;156(12):880-891.
  31. Huh WK, Ault KA, Chelmow D, et al. Use of primary high-risk human papillomavirus testing for cervical cancer screening: interim clinical guidance. Gynecol Oncol. 2015;136(2):178-182.
  32. American College of Obstetricians and Gynecologists. Committee Opinion No. 512. Health Care for Transgender Individuals. 2011.
  33. Dinkelspiel H, Fetterman B, Poitras N, et al. Screening history preceding a diagnosis of cervical cancer in women age 65 and older. Gynecol Oncol. 2012;126(2):203-206.
  34. National Center for Health Statistics. Health, United States, 2015: With Special Feature on Racial and Ethnic Health Disparities.Report No. 2016-1232. Hyattsville, MD: National Center for Health Statistics; 2016.
  35. CDC. Increasing Population-based Breast and Cervical Cancer Screenings: An Action Guide to Facilitate Evidence-based Strategies. Atlanta, GA: CDC, U.S. Department of Health and Human Services; 2014.

Approved by the NPWH Board of Directors: March 2018


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